基本属性 生物活性体外研究体内研究 用途与合成方法 供应商 供应信息

223763-80-2

223763-80-2

中文名称:223763-80-2
英文名称:Bestatin (trifluoroacetate)
CAS号:223763-80-2
分子式:C18H25F3N2O6
分子量:422.4
EINECS号:
Mol文件:223763-80-2.mol
223763-80-2 结构式

223763-80-2 性质

储存条件 Store at -20°C
溶解度 溶于二甲基亚砜

223763-80-2 用途与合成方法

Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,常用于癌症研究。

Bestatin enhances ATRA-induced differentiation and inhibits ATRA-driven phosphorylation of p38 MAPK in ATRA-sensitive APL NB4 cells. Bestatin can not reverse the differentiation block in ATRA-resistant APL MR2 cells. CD13 ligation with anti-CD13 antibody WM-15 results in phosphorylation of p38 MAPK, reduces the inhibition of Bestatin on the phosphorylation of p38 MAPK, and completely abolishes the enhancement of Bestatin on ATRA-inducing differentiation in NB4 cells. Bestatin (600 μM)-treated cells progress slower through the cell cycle due to decreased rate of cell growth and the frequency of cell division. Bestatin inhibits the frequency of mitosis and the inherent multinuclearity in D. discoideum, and is not cytotoxic to D. discoideum cells at 0-600 μM. Bestatin inhibits aminopeptidase activity in lysates of PsaA-GFP- and GFP-expressing cells by 69.39% ± 10.5% and 39.93% ± 18.7% of control, respectively.

Bestatin (20 μM) significantly reduces CD13 expression in diabetic mice and results a significant inhibition of MMP-9 specific gelationolytic band densities compared to diabetic vehicle-treated mice. Bestatin treatment significantly inhibits the expression of VEGF and heparanase in diabetic mice. Intravitreal bestatin treatment significantly downregulates the expression of both HIF-1α and VEGF in diabetic mice retinas. Furthermore, the upregulated expression of heparanase in diabetic mice retinas is significantly inhibited by intravitreal bestatin treatment. Bestatin (10, 1, and 0.1mg/kg, i.p.) treatment before the antigen-potentiated humoral response to SRBC results in an increased number of splenocytes producing hemolytic anti-SRBC antibodies (PFC) and the 2-ME-resistant serum hemagglutinin titer (at a dose of 0.1 mg/kg). Bestatin (1 and 0.1 mg/kg) administered to mice five times on alternate days after cyclophosphamide injection does not change the suppressive effect of the drug regarding the number of PFC, and even causes the further decrease of the total anti-SRBC hemagglutinins at dose of 1 mg/kg on day 7 after antigen stimulation.

223763-80-2供应商 更多

爱必信(上海)生物科技有限公司
联系电话:021-38015121 15000105423
产品介绍:
英文名称:Bestatin trifluoroacetate
CAS:223763-80-2
包装信息:10mg;50mg
备注: 见爱必信官网
天津普西唐生物医药科技有限公司
联系电话:010-60605840
产品介绍:
中文名称:乌苯美司三氟乙酸盐
英文名称:Bestatin trifluoroacetate
CAS:223763-80-2
包装信息:100mg
备注: 试剂级
TargetMol中国(陶术生物)
联系电话: 4008200310
产品介绍:
中文名称:化合物 Bestatin trifluoroacetate
英文名称:Bestatin trifluoroacetate
CAS:223763-80-2
纯度:98%
包装信息:100 mg;5 mg;50 mg
上海一研生物科技有限公司
联系电话:021-69985186 13611928337
产品介绍:
英文名称:Bestatin trifluoroacetate
CAS:223763-80-2
备注:1盒

最新发布供应信息

223763-80-2Bestatin trifluoroacetate
上海一研生物科技有限公司 2024-06-12