Step A: Synthesis of racemic-7-methoxy-indan-1-ylamine
A mixture of 7-methoxy-indan-1-one oxime (CAS 908108-58-7, containing (E)-oxime, CAS 179899-16-2) (22.3 g, 126 mmol) was reacted with nickel ryenne (11.26 g) in a mixture of solvents of tetrahydrofuran (570 mL) and methanol (570 mL) at 100 bar of hydrogen pressure at 60 °C for Hydrogenation reaction was carried out for 22 hours. Upon completion of the reaction, the catalyst was removed by filtration and washed with methanol and tetrahydrofuran. Subsequently, all volatiles were removed by vacuum distillation to afford 7-methoxy-1-indenamine as a brown oil (19.95 g, 97% yield, HPLC retention time 0.4 min). Mass spectrometry (ISP) analysis showed m/e = 164.2 [(M+H)+].
