Quinoline, 6-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-, ( )-

Product NameQuinoline, 6-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-, ( )-
CAS147527-31-9
MFC22H23N3O4S
MW425.50072
EINECS
MOL File147527-31-9.mol

Chemical Properties

Density	1.36±0.1 g/cm3(Predicted)
storage temp.	-20C
solubility	DMSO: 50mg/mL
form	Off-white solid
pka	10.54±0.60(Predicted)
color	White to off-white

Usage And Synthesis

Uses

(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca2+ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function[1].

Biological Activity

Cell permeable: yes', 'Primary Target
myosin', 'Reversible: yes

in vivo

(+)-EMD 57033 (0.4 or 0.8 mg/kg/min; i.v.drip; over than 20 min) enhances contractility and achieves Ca²⁺ sensitization in intact failing hearts at substantial energetic savings and without compromise of diastolic function in dogs^[4].

Animal Model:	Mongrel dogs implanted with a micromanometer in left ventricle (LV) at the apex via lateral thoracotomy^[4]
Dosage:	0.4 or 0.8 mg/kg/min
Administration:	Intravenous drip; infused over 20 minutes
Result:	Enhanced contractility at both doses, with similar changes in CON (conscious dogs) and HF (heart failure dogs) hearts. Decreased the end-diastolic pressure (EDP) and lowered arterial load or preload at 0.8 mg/kg/min.

References

[1] Wang X, et al. Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033. J Biol Chem. 2001 Jul 6;276(27):25456-66. DOI:10.1074/jbc.M102418200
[2] Ochala J, et al. EMD 57033 partially reverses ventilator-induced diaphragm muscle fibre calcium desensitisation. Pflugers Arch. 2010 Feb;459(3):475-83. DOI:10.1007/s00424-009-0744-1
[3] Hgashiyama A, et al. Effects of EMD 57033 on contraction and relaxation in isolated rabbit hearts. Circulation. 1995 Nov 15;92(10):3094-104. DOI:10.1161/01.cir.92.10.3094
[4] Senzaki H, et al. Improved mechanoenergetics and cardiac rest and reserve function of in vivo failing heart by calcium sensitizer EMD-57033. Circulation. 2000 Mar 7;101(9):1040-8. DOI:10.1161/01.cir.101.9.1040

Quinoline, 6-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro-, ( )- Supplier

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