基本属性 生物活性靶点体外研究体内研究 用途与合成方法 Kynurenic acid sodium salt 价格(试剂级) 供应商 供应信息

Kynurenic acid sodium salt

Kynurenic acid sodium salt

英文名称:Kynurenic acid sodium salt
CAS号:2439-02-3
分子式:C10H6NNaO3
分子量:230.19571
EINECS号:
Mol文件:2439-02-3.mol
Kynurenic acid sodium salt 结构式

Kynurenic acid sodium salt 性质

储存条件 Store at RT
溶解度 DMSO : 50 mg/mL (235.67 mM; 需要超声波)H2O : < 0.1 mg/mL (不溶)
形态 粉末
颜色 白色

Kynurenic acid sodium salt 用途与合成方法

Kynurenic acid sodium 是一种内源性色氨酸代谢物,是针对靶点 NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光谱性拮抗剂。Kynurenic acid sodium 也是 GPR35/CXCR8 的激动剂。

Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine

GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [ 35 S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range.

Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.

Kynurenic acid sodium salt 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-107512 Kynurenic acid sodium salt 2439-02-3 100mg 500
2024-11-08 HY-107512 Kynurenic acid sodium salt 2439-02-3 10mM * 1mLin DMSO 550

Kynurenic acid sodium salt供应商 更多

武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:Kynurenic acid sodiuM salt;4-Hydroxyquinoline-2-carboxylicacidsodiuMsalt
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
北京普西唐生物科技有限公司
联系电话:010-60605840 18892239720
产品介绍:
英文名称:Kynurenic acid sodium
CAS:2439-02-3
纯度:98%
包装信息:100mg
MedBio脉铂医药
联系电话:021-69568360 18916172912
产品介绍:
英文名称:Kynurenic acid sodium salt
CAS:2439-02-3
纯度:98%
包装信息:10mM (in 1mL DMSO); 100mg
备注:Medbio
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:Kynurenic acid sodium
CAS:2439-02-3
纯度:98%
包装信息:100mg
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Kynurenic acid sodium
CAS:2439-02-3
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen

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