Kynurenic acid sodium salt
Kynurenic acid sodium salt 性质
储存条件 | Store at RT |
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溶解度 | DMSO : 50 mg/mL (235.67 mM; 需要超声波)H2O : < 0.1 mg/mL (不溶) |
形态 | 粉末 |
颜色 | 白色 |
Kynurenic acid sodium salt 用途与合成方法
Target: GPR35, NMDA, glutamate, glutamate, α7 nicotinic acetylcholine
GPR35 functions as a receptor for the kynurenine pathway intermediate kynurenic acid. Kynurenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manner in the presence of G qi/o chimeric G proteins. Kynurenic acid stimulates [ 35 S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment. Kynurenic acid also induces the internalization of GPR35. KYNA’s neuroinhibitory qualities and its neuroprotective and anticonvulsant effects are discovered using concentrations of the compound in the millimolar range. This, as well as the low affinity of KYNA at each of the three ionotropic glutamate receptors responsible for these effects [NMDA, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate], together with the realization that KYNA concentrations in the mammalian brain are in the sub-micromolar range, suggested that other receptors might serve as targets of endogenous Kynurenic acid. Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range.
Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. The lowest Kynurenic acid dose stimulates the proliferative response of T lymphocytes (p<0.05), after 7 and 28 days of administering the acid to the animals.
Kynurenic acid sodium salt 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024-11-08 | HY-107512 | Kynurenic acid sodium salt | 2439-02-3 | 100mg | 500 |
2024-11-08 | HY-107512 | Kynurenic acid sodium salt | 2439-02-3 | 10mM * 1mLin DMSO | 550 |