(8'aR)-2',3',8',8'a-Tetrahydro-5',6'-dimethoxyspiro[2,5-cyclohexadiene-1,7'(1'H)-cyclopenta[ij]isoquinoline]-4-one

A spiroisoquinoline alkaloid from Stephania glabra, the base has [α]²⁶_D + 143° (c 1.88, CHCI3). It contains two methoxyl groups and an imino group and yields a crystalline N-acetyl derivative, m.p. 234-5°C; [α]²⁴_D- 80° (c 1.57, CHCI3). The N-methyl compound has been shown to be identical with Pronuciferine (q.v.).

Cava et al., Chern. Ind., 282 (1964)
Tomita et al., Tetrahedron Lett., 2825 (1965)
Baldwin et al., J. Chern. Soc., C, 154 (1967)
Circular dichroism: Snatzke, Wollenberg., J. Chern. Soc., C, 1681 (1966)