Anti-Apolipoprotein E Receptor 2, Anti-Low Density Lipoprotein Receptor-Related Protein 8, Anti-LRP8

Anti-ApoER2 antibody produced in rabbit has been used in western blot analysis.

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) is expressed predominantly in the brain and placenta. This gene is located on human chromosome 1p32.

Apolipoprotein E receptor 2 (ApoER2, also known as LRP8) play an important role in the endocytosis of plasma lipoproteins, including ApoE and cholesterol metabolism. In the central nervous system, ApoER2 mediates various neuronal signaling mechanisms during neuronal development, affecting neurite outgrowth, synapse formation and neuronal migration, and neuronal survival in response to acute damage. ApoER2 plays a central role in the reelin/Dab1 signaling pathway that controls neuronal positioning during brain development as well as long-term potentiation (LTP) in the adult brain.