Neuropeptide EI (rat) (trifluoroacetate salt)

Neuropeptide EI (NEI) is an endogenous peptide fragment of rat prepro-melanin concentrating hormone (MCH) that is involved in hormone release, grooming behavior, and motor activity.1 NEI corresponds to amino acids 140-152 of rat prepro-MCH and 131-143 of human, mouse, and rat prepro-MCH. It is expressed in both the central and peripheral nervous systems, localizes to the cytoplasm, and colocalizes with MCH in the CNS.1,2 NEI (1 µM) reduces thyrotropin-releasing hormone (TRH) release in mediobasal hypothalamus explants.3 Intracerebroventricular administration of NEI increases serum levels of luteinizing hormone (LH) in male rats and in chronically ovariectomized female rats that received estradiol benzoate and progesterone in addition to NEI.4 NEI (1 µg/animal, i.c.v.) induces excessive grooming behavior and increases locomotor activity in rats, effects that can be blocked by MCH (Item No. 24462) or α-melanocyte-stimulating hormone (α-MSH; Item No. 29923).5 It also increases the amount of time spent in REM sleep in rats when injected intracerebroventricularly or into the ventrolateral periaqueductal grey (vlPAG).WARNING This product is not for human or veterinary use.

[1] JACKSON BITTENCOURT  María E C. Anatomy, function and regulation of neuropeptide EI (NEI)[J]. Peptides, 2008, 29 8: Pages 1441-1450. DOI: 10.1016/j.peptides.2008.03.012
[2] BITTENCOURT J C. Anatomical organization of the melanin-concentrating hormone peptide family in the mammalian brain[J]. General and comparative endocrinology, 2011, 172 2: Pages 185-197. DOI: 10.1016/j.ygcen.2011.03.028
[3] A. KENNEDY. Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release, in vivo and in vitro, via the hypothalamus and the pituitary.[J]. Endocrinology, 2001, 56 1: 3265-3268. DOI: 10.1210/endo.142.7.8374
[4] ANDRÉS M. ATTADEMO . Intracerebroventricular injection of neuropeptide EI increases serum LH in male and female rats[J]. Peptides, 2004, 25 11: Pages 1995-1999. DOI: 10.1016/j.peptides.2004.06.010
[5] M. SANCHEZ  M. C  B I Baker. Melanin-Concentrating Hormone (MCH) Antagonizes the Effects of α-MSH and Neuropeptide E-I on Grooming and Locomotor Activities in the Rat[J]. Peptides, 1997, 18 3: Pages 393-396. DOI: 10.1016/s0196-9781(96)00327-0