L-Folinic Acid (calcium salt hydrate)

L-Folinic acid is a reduced folic acid and isomer of DL-folinic acid (Item No. 20383).1 Formulations containing DL-folinic acid, a racemic mixture of D-folinic acid and L-folinic acid, that have been used to prevent toxicity following therapy with high-dose methotrexate, to enhance the antitumor activity of 5-fluorouracil, and as a folate supplement.2,3 Clinical studies demonstrate that formulations containing L-folinic acid have similar efficacy and tolerability as those contianing DL-folinic acid and have been used interchangeably for modification of antitumor activity of 5-fluorouracil, while D-folinic acid is inactive.1WARNING This product is not for human or veterinary use.

[1] PHILIP A. KOVOOR  John L M  Syed Mustafa Karim. Is Levoleucovorin an Alternative to Racemic Leucovorin A Literature Review[J]. Clinical colorectal cancer, 2009, 8 4: Pages 200-206. DOI: 10.3816/ccc.2009.n.034
[2] PETER V. DANENBERG . Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action[J]. Critical reviews in oncology/hematology, 2016, 106: Pages 118-131. DOI: 10.1016/j.critrevonc.2016.08.001
[3] RICHARD E FRYE. A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel.[J]. Frontiers in Public Health, 2013, 1: 31. DOI: 10.3389/fpubh.2013.00031