β-Glycerophosphate-d5 (sodium salt hydrate)

β-Glycerophosphate-d5 is intended for use as an internal standard for the quantification of β-glycerophosphate (Item No. 38367) by GC- or LC-MS. β-Glycerophosphate is an inhibitor of alkaline phosphatase.1 It decreases alkaline phosphatase activity and promotes bone mineralization in chick osteoblasts when used at concentrations of 10 and 20 mM. β-Glycerophosphate (10 mM) induces calcification of cultured bovine vascular smooth muscle cells (BVSMCs) in an alkaline phosphatase-dependent manner.2WARNING This product is not for human or veterinary use.

[1] C H CHUNG. Mechanism of action of beta-glycerophosphate on bone cell mineralization.[J]. Calcified Tissue International, 1992, 51 4: 305-311. DOI: 10.1007/bf00334492
[2] A SHIOI. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells.[J]. Arteriosclerosis, Thrombosis, and Vascular Biology, 1995, 15 11: 2003-2009. DOI: 10.1161/01.atv.15.11.2003