Oleoyl-Coenzyme A (sodium salt)

Oleoyl-coenzyme A (oleoyl-CoA) is a thioester of oleic acid (Item No. 90260 | 24659) and CoA (Item Nos. 16147 | 21499 | 21722). It is a substrate for several acyl-CoA-dependent enzymes, including acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), ACAT-2, acyl-CoA dehydrogenase-9 (ACAD-9), membrane-bound O-acyltransferase 1 (MBOAT1), and MBOAT2.1,2,3 Oleoyl-CoA binds the fatty acid metabolism regulator protein (FadR) promoter in E. coli (Ki = 0.005 µM).4 Oleoyl-CoA (1 µM) activates sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 in Xenopus oocytes.5WARNING This product is not for human or veterinary use.

[1] TORU SEO. Differential Modulation of ACAT1 and ACAT2 Transcription and Activity by Long Chain Free Fatty Acids in Cultured Cells†[J]. Biochemistry Biochemistry, 2001, 40 15: 4756-4762. DOI: 10.1021/bi0022947
[2] REGINA ENSENAUER. Human acyl-CoA dehydrogenase-9 plays a novel role in the mitochondrial beta-oxidation of unsaturated fatty acids.[J]. The Journal of Biological Chemistry, 2005, 280 37: 32309-32316. DOI: 10.1074/jbc.m504460200
[3] MIGUEL A GIJÓN. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils.[J]. The Journal of Biological Chemistry, 2008, 283 44: 30235-30245. DOI: 10.1074/jbc.m806194200
[4] C. DIRUSSO A M Tamra L Heimert. Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A.[J]. The Journal of Biological Chemistry, 1992, 17 1: 8685-8691. DOI: 10.1016/s0021-9258(18)42497-0
[5] F M GRIBBLE. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA.[J]. The Journal of Biological Chemistry, 1998, 273 41: 26383-26387. DOI: 10.1074/jbc.273.41.26383