P2X3 antagonist 38 (compound 4) is a potent and orally active P2X3 antagonist with IC50 values of 0.132, 0.165, 0.421 μM for hP2X3, rP2X3, gpP2X3, respectively[1].
IC 50
P2X3 Receptor: 0.132 μM (IC50)
References
[1] YunFeng Chen, et al. N-carboxamidopyrazoline derivative serving as p2x3 receptor antagonist and applications. WO2022028154A1.
