1,4,7-triazacyclononane-N,N',N''-triacetic acid

Product Name1,4,7-triazacyclononane-N,N',N''-triacetic acid
CAS56491-86-2
MFC12H21N3O6
MW303.31
EINECS
MOL File56491-86-2.mol

Chemical Properties

Boiling point	572.9±50.0 °C(Predicted)
Density	1.321±0.06 g/cm3(Predicted)
storage temp.	-20°C, protect from light
form	Solid
pka	1.82±0.10(Predicted)
color	White to off-white
Water Solubility	Water : 125 mg/mL (412.12 mM; Need ultrasonic)

Usage And Synthesis

Description

NOTA is a bifunctional chelating agent that shows high complexation constant with metals, such as gallium.

Uses

NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools. NOTA also can be used for probe design and signal amplification via the multivalent effect. NOTA can be used in multiple myeloma, breast cancer, lymphoma and myocardial infarction research[1][2][3][4][5][6].

in vivo

NOTA participates in the synthesis of [⁶⁴Cu]NOTA-pentixather to enables high resolution PET imaging of CXCR4 expressionin in Daudi lymphoma-bearing severe combined immunodeficiency (SCID) mice ^[3].
NOTA participates in the synthesis of ⁶⁸Ga-NOTA-RGD for MicroPET/CT imaging of α_vβ₃integrin in rat myocardial infarction^[4].
NOTA participates in the synthesis of [⁶⁸Ga]Ga-NOTA-Nb1053 for immunoPET imaging of multiple myeloma^[5].
NOTA is a superior chelator to DOTA for PET imaging with ⁶⁴Cu-labeled TRC105 in 4T1 murine breast tumor-bearing mice^[6].

IC 50

RDC Bifunctional Chelator

References

[1] Singh AN, et al. Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem. 2011;22(8):1650-1662. DOI:10.1021/bc200227d
[2] Liao AH, et al. Evaluation of 18F-labeled targeted perfluorocarbon-filled albumin microbubbles as a probe for microUS and microPET in tumor-bearing mice. Ultrasonics. 2013;53(2):320-327. DOI:10.1016/j.ultras.2012.06.014
[3] Poschenrieder A, et al. [64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model. EJNMMI Radiopharm Chem. 2017;2(1):2. DOI:10.1186/s41181-016-0020-6
[4] Menichetti L, et al. MicroPET/CT imaging of αvβ? integrin via a novel ??Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction. Eur J Nucl Med Mol Imaging. 2013 Aug;40(8):1265-74. DOI:10.1007/s00259-013-2432-9
[5] Wang C, et al. ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053. Eur J Nucl Med Mol Imaging. 2021 Aug;48(9):2749-2760. DOI:10.1007/s00259-021-05218-1
[6] Zhang Y, et al. Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA. PLoS One. 2011;6(12):e28005. DOI:10.1371/journal.pone.0028005

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