N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺
N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺
N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 性质
| 沸点 | 442.6±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 二甲基亚砜：250 mg/mL（942.29 mM） |
| 酸度系数(pKa) | 2.42±0.50(Predicted) |
| 形态 | 固体 |
| 颜色 | 浅黄至黄色 |
N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 用途与合成方法
| Target | Value |
|
seminal vesicle prostaglandin synthetase
(Cell-free assay) | 3.1 μM |
|
RBL-1 cytosolic 5-LOX
(Cell-free assay) | 3.5 μM |
FPL 62064 inhibits both 5-1ipoxygenase (IC 50 of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC 50 of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC 50 of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC 50 of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC 50 s for leukotriene (IC 50 of 0.72 μM) and prostaglandin (IC 50 of 0.43 μM) production are similar.
FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex.
| Animal Model: | Female LACA mice (20-30 g) injected with immune complex. |
| Dosage: | 5 mg/kg, 10 mg/kg, 20 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Produced a dose-related inhibition of dye extravasation, leukotriene C 4 (LTC 4 ) and prostaglandin E 2 (PGE 2 ) formation. |
N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-02-08 | HY-105024 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 | 103141-09-9 | 1 mg | 571 |
| 2025-02-08 | HY-105024 | N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 | 103141-09-9 | 5mg | 1500 |
