1-acetyl-3,2-toluyl-5-fluorouracil
英文名称:1-acetyl-3,2-toluyl-5-fluorouracil
CAS号:71861-76-2
分子式:C14H11FN2O4
分子量:290.25
EINECS号:
Mol文件:71861-76-2.mol
1-acetyl-3,2-toluyl-5-fluorouracil 性质
熔点 | 141-143 °C(Solv: ethyl ether (60-29-7)) |
---|---|
沸点 | 408.8±55.0 °C(Predicted) |
密度 | 1.44±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | -5.29±0.40(Predicted) |
1-acetyl-3,2-toluyl-5-fluorouracil 用途与合成方法
1-Acetyl-3-o-toluyl-5-fluorouracil是有效的抗肿瘤剂。
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).
1-acetyl-3,2-toluyl-5-fluorouracil供应商 更多
天津普西唐生物医药科技有限公司
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产品介绍:
英文名称:1-Acetyl-3-o-toluyl-5-fluorouracil
CAS:71861-76-2
纯度:95%
包装信息:1g