(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .
Intermediate of Azithromycin. Antibacterial agent.
Erythromycin A 9-oxime is a semi-synthetic analogue of erythromycin prepared as means of overcoming acid lability and improving oral absorption of erythromycin A while retaining comparable antibacterial and potency. Although not developed as a commercial product, erythromycin oxime was pivotal in the development of the ring expanded aza-erythromycins (e.g. azithromycin) and the oxime ethers (e.g. roxithromycin).
(9E)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans. It has anti-Helicobacter pylori activity
[1] D ZHONG. Identification of the metabolites of roxithromycin in humans.[J]. Drug Metabolism and Disposition, 2000, 28 5: 552-559.
