The general procedure for the synthesis of 2-chloro-4-methylpyrimidine-5-carboxylic acid from ethyl 4-methyl-2-chloropyrimidine-5-carboxylate is as follows:
Example 9: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (1.0 g, 5 mmol) was reacted with an aqueous solution (30 mL) of NaOH (0.24 g, 6 mmol) with stirring at room temperature for 3 hours. After completion of the reaction, the reaction solution was acidified with 6N HCl and the precipitated solid was filtered and dried to afford 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.67 g, 78% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.01 (s, 1H), 2.75 (s, 3H).
