BOC-(TRANS)-4-(3-BROMO-PHENYL)-PYRROLIDINE-3-CARBOXYLIC ACID

(3R,4S)-4-(3-Bromophenyl)-1-(tert-butoxycarbonyl)-pyrrolidine-3-carboxylic Acid is used to prepare substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors, aryl substituted pyrrolidines.