Basic information Safety Related Supplier

Rituximab

Basic information Safety Related Supplier
Rituximab Basic information
Rituximab Usage And Synthesis
  • UsesAntineoplastic (microtubule inhibitor); monoclonal antibody.
  • brand nameRituxan (IDEC).
  • General DescriptionRituximab (Rituxan, Chimeric) is an MAb directed againstthe CD20 antigen expressed on the surfaces of normal andmalignant B lymphocytes. The MAb is produced in mammalian(CHO) suspension culture and is a chimeric(murine/human) MAb of the IgG1 κ type. The protein is composed of murine light and heavy chain variable regionsand human constant regions. Rituximab is indicated for thetreatment of patients with relapsed or refractory, low-gradeor follicular, CD20(+) B-cell non-Hodgkin lymphoma.Rituximab binds specifically to antigen CD20 (human Blymphocyte–restricted differentiation antigen, a hydrophobictransmembrane protein expressed on pre-B and matureB lymphocytes). CD20 is a protein of 35 to 37 kDa, and itmay play a role in B cell activation and regulation and maybe a calcium ion channel. The antigen is also expressed onmore than 90% of non-Hodgkin lymphoma B cells but is notfound on hematopoietic stem cells, pro-B cells, normalplasma cells, or other normal tissues. CD20 regulates theearly steps in the activation process for cell cycle initiationand differentiation.
Rituximab()Related Product Information
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  • Company Name:Wuhan Sunrise Technology Development Co., Ltd.
  • Tel:13554138826
  • Email:whsrtech@vip.163.com;whsrtech@vip.163.com
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  • Company Name:Beijing HuaMeiHuLiBiological Chemical
  • Tel:010-56205725
  • Email:waley188@sohu.com
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  • Company Name:Shanghai Synchem Pharma Co., ltd
  • Tel:18016477331 021-61984905-1
  • Email:synchempharma@aliyun.com
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  • Company Name:Shanghai Hanjing Chemicals Co., Ltd.
  • Tel:13641685631 021-54285032
  • Email:gerry.shu@hanjingchemicals.com
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