9(S)-HODE-13C18

9(S)-HODE-13C18 is intended for use as an internal standard for the quantification of 9-HODE by GC- or LC-MS. (±)-9-HODE is formed via non-enzymatic oxidation of linoleic acid (Item Nos. 90150 | 90150.1 | 21909).1 9(S)-HODE and 9(R)-HODE are formed by lipoxygenase- and cyclooxygenase-mediated oxidation of linoleic acid, respectively.2,3,4WARNING This product is not for human or veterinary use.

[1] PETER SPITELLER  Gerhard S. 9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE): excellent markers for lipid peroxidation[J]. Chemistry and Physics of Lipids, 1997, 89 2: Pages 131-139. DOI: 10.1016/s0009-3084(97)00070-4
[2] GARDNER H W. Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989, 1001 3: Pages 274-281. DOI: 10.1016/0005-2760(89)90111-2
[3] HARTMUT KÜHN  Rainer W  Jutta BELKNER. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes*[J]. The FEBS journal, 1990, 191 1: 221-227. DOI: 10.1111/j.1432-1033.1990.tb19113.x
[4] NURIA GODESSART . Prostaglandin H-Synthase-2 Is the Main Enzyme Involved in the Biosynthesis of Octadecanoids from Linoleic Acid in Human Dermal Fibroblasts Stimulated with Interleukin-1β[J]. Journal of Investigative Dermatology, 1996, 107 5: Pages 726-732. DOI: 10.1111/1523-1747.ep12365616