SB 243213
SB 243213 用途与合成方法
|
Human 5-HT 2C Receptor 9.37 (pKi) |
human 5-HT 1A Receptor <5.3 (pKi) |
human 5-HT 1B Receptor 5.5 (pKi) |
human 5-HT 1D Receptor 6.32 (pKi) |
human 5-HT 1E Receptor <5.4 (pKi) |
human 5-HT 1F Receptor 5.35 (pKi) |
Human 5-HT 2A Receptor 7.01 (pKi) |
human 5-HT 2B Receptor 7.2 (pKi) |
Human 5-HT 6 Receptor 6.5 (pKi) |
Human 5-HT 7 Receptor 5.64 (pKi) |
SB 243213 shows little affinity (pK
i
<6) for cloned human 5-HT
1A
, 5-HT
1B
, 5-HT
1E
, 5- HT
1F
and 5-HT
7
receptors. It shows weak affinity (pK
i
<6.5) for the cloned human 5-HT
1D
and D3 receptors and moderate affinity (pK
i
=6.7) for the cloned human D2 receptor.
SB 243213 (0.1-10 mg/kg, p.o. 1 h pre-test) dose-dependently and significantly increases the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box.
SB 243213 (0.3 mg/kg; p.o.; 1 h pre-test) significantly increases time spent in social interaction.
| Animal Model: | Male Sprague-Dawley experimentally naive rats (220-300 g) |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | PO; 1 hour pre-test |
| Result: | Dose-dependently and significantly increased the amount of time rats spent in social interaction over 15 min under brightly lit conditions and in an unfamiliar test box. |
SB 243213 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-103112B | 200940-22-3 | 5mg | 900 | |
| 2026-09-15 | HY-103112B | 200940-22-3 | 10mM * 1mLin DMSO | 990 |
