6-クロロアントラニル酸

外観

微褐色～褐色、結晶～結晶性粉末

用途

有機合成原料。

化学的特性

white to light yellow crystal powder

使用

2-Amino-6-chlorobenzoic acid is used as intermediate for medicine.

主な応用

The tricyclohexyltin 2-amino-6-chlorobenzoate was synthesized by the reaction of the tricyclohexyltin hydroxide with the 2-amino-6-chlorobenzoic acid.

製造方法

A, in the reaction vessel being provided with agitator, thermometer, reflux condenser, Dropping funnel, add cerium chloride 0.16mol, 4-hydroxy 3-methoxybenzene ethanol solution 0.19mol, Klorvess Liquid 400-500ml, control mixing speed and exist 160-190rpm, rising solution temperature, to 60-65°C, is slowly added to 2-chloro-6-nitrobenzoyl acid solution 0.13mol, sulfurous acid Hydrogen potassium solution 200ml, raises mixing speed to 260-310rpm, back flow reaction 5-7h；
B, reduction solution temperature, to 15-19°C, separate out solid, filter, and add diammonium hydrogen citrate solution 150-in filtrate 180ml, concentrating under reduced pressure, separate out solid, filter, dehydrant is dehydrated, brine, and pyridine solution washs, ethyl acetate solution Middle recrystallization, obtains crystal 2-amino-6-chlorobenzoic acid (C7H6ClNO2).