DICHLOROPHENYL-ABA
DICHLOROPHENYL-ABA 性质
| 熔点 | 245 °C |
|---|---|
| 沸点 | 420.8±45.0 °C(Predicted) |
| 密度 | 1.470±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | DMSO:~18 mg/mLat ~60 °C |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.62±0.36(Predicted) |
| 颜色 | 白色 |
DICHLOROPHENYL-ABA 用途与合成方法
Transthyretin (TTR) amyloid fibril formation
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.
DICHLOROPHENYL-ABA 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-113950 | DICHLOROPHENYL-ABA | 18201-65-5 | 1 mg | 1080 |
| 2026-09-15 | HY-113950 | DICHLOROPHENYL-ABA | 18201-65-5 | 5 mg | 2800 |
