Azidoethyl-PEG2-t-Butyl ester is a PEG linker that contains a cleavable disulfide bond, an azide group and a t-butyl ester group. The disulfide bond can be cleaved via reduction reactions. The azide group can be reacted with an alkyne, DBCO or BCN moiety to undergo copper-catalyzed Click Chemistry. The t-butyl ester group can be removed under acidic conditions.
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azidoethyl-SS-PEG2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
