(S)-(+)-Clopidogrel-d3 is intended for use as an internal standard for the quantification of (S)-(+)-clopidogrel (Item No. 21002) by GC- or LC-MS. (S)-(+)-Clopidogrel is a prodrug form of the active metabolite of clopidogrel, which is a purinergic P2Y12 receptor antagonist.1 It inhibits aggregation of rat platelets induced by ADP, collagen, or thrombin ex vivo (ID50s = 4, 4.8, and 2.9 mg/kg, respectively). (S)-(+)-Clopidogrel increases tail bleeding time in rats in a dose-dependent manner. Formulations containing (S)-(+)-clopidogrel have been used in the treatment of acute coronary syndrome and peripheral artery disease and to reduce the reoccurrence of myocardial infarction and stroke.WARNING This product is not for human or veterinary use.
