COP9 signalosome complex subunit 6 belongs to the multisubunit COP9 signalsome which modulates protein ubiquitination to affect cellular processes such as cell-cycle progression and DNA damage repair. COPS6 is a putative oncogene that has been shown to be overexpressed in a significant percentage of colorectal cancers with poor prognosis. Mechanistically, research studies have shown that a signaling axis involving EGFR and ERK promotes tumor growth through the phosphorylation of COPS6, which indirectly facilitates downstream stabilization of β-catenin and enhancement of its transcriptional acitivity. Reasearch studies have also demonstrated that COPS6 contributes to tumorigenesis through the stabilization of other oncoproteins like c-Myc, MDM2 and E6AP.
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