Calcitonin Gene Related Peptide (CGRP) II, rat

Product NameCalcitonin Gene Related Peptide (CGRP) II, rat
CAS99889-63-1
MF
MW0
EINECS
MOL FileMol File

Chemical Properties

Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)

Usage And Synthesis

Uses

Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases[1].

in vivo

Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats^[5].

Animal Model:	Male Sprague-Dawley rats^[5].
Dosage:	0.01 ng/kg-3 μg/kg (100 μL), succeeded by a 150 μL isotonic saline flush, at 10 min intervals.
Administration:	A bolus injection
Result:	Induced PA (pial artery) dilatation and increased in LCBF_Flux (local cortical cerebral blood flow).

References

[1] D Wu, et al. Development and potential of non-peptide antagonists for calcitonin-gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity. Biochem Soc Trans. 2002 Aug;30(4):468-73. DOI:10.1042/bst0300468
[2] F M Wisskirchen, et al. CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification. Br J Pharmacol. 2000 May;130(2):464-70. DOI:10.1038/sj.bjp.0703315
[3] K Husmann, et al. Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol. 2000 Apr 25;162(1-2):35-43. DOI:10.1016/s0303-7207(00)00212-4
[4] M Sheykhzade, et al. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol. 1998 Apr;123(7):1464-70. DOI:10.1038/sj.bjp.0701760
[5] Kenneth A Petersen, et al. Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat. Br J Pharmacol. 2004 Nov;143(6):697-704. DOI:10.1038/sj.bjp.0705966

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