D-Mannose-6-phosphate (sodium salt hydrate)

D-Mannose-6-phosphate (M6P) is a phosphorylated aldohexose that has diverse physiological roles. It can be used to produce glucose as an energy source, converted to mannitol to serve as an osmolyte or metabolic store, or directed to the N-glycosylation pathway. M6P is also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to mannose receptor homology domains on other proteins.

[1] VANDANA SHARMA; Hudson H F; Mie Ichikawa. Mannose metabolism: More than meets the eye[J]. Biochemical and biophysical research communications, 2014, 453 2: Pages 220-228. DOI: 10.1016/j.bbrc.2014.06.021
[2] MUKESH MEENA. Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.[J]. Frontiers in Microbiology, 2015: 1019. DOI: 10.3389/fmicb.2015.01019
[3] SCHULZE H, BARTELSEN O, SCHEPERS U, et al. Expression of human acid ceramidase in insect cells. Analysis of processing, glycosylation and disulfide bond pattern.[C]. 2007: 0. DOI: 10.1240/sav_gbm_2007_m_001721
[4] J. SARIS. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin.[J]. American journal of physiology. Heart and circulatory physiology, 2001, 280 4 1: H1706-15. DOI: 10.1152/ajpheart.2001.280.4.h1706
[5] CECILIA D’ALESSIO; Nancy M D. Glucosidase II and MRH-domain containing proteins in the secretory pathway.[J]. Current protein peptide science, 2015, 16 1: 31-48. DOI: 10.2174/1389203716666150213160438
[6] NOBUKO HOSOKAWA; Koichi K;Yukiko Kamiya. The role of MRH domain-containing lectins in ERAD.[J]. Glycobiology, 2010, 20 6: 651-660. DOI: 10.1093/glycob/cwq013