Polymyxin B2 sulfate

Polymyxin B2 Sulfate is a polypeptide antibiotic that has antibacterial activity, particularly against gram-negative bacteria. Polymyxin B2 Sulfate kills the bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting the integrity of the cell membrane and causing the cell contents to leak. Polymyxin B2 Sulfate can be used in antibiotic development and treatment of drug-resistant strains[1].

[1] Meng M, et al. Simultaneous quantitation of polymyxin B1, polymyxin B2 and polymyxin B1-1 in human plasma and treated human urine using solid phase extraction and liquid chromatography–tandem mass spectrometry[J]. Journal of Chromatography B, 2016, 1012: 23-36. DOI:10.1016/j.jchromb.2016.01.013
[2] KADE D. ROBERTS. Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria[J]. ACS Infectious Diseases, 2015, 1 11: 568-575. DOI: 10.1021/acsinfecdis.5b00085