DCG IV
DCG IV 性质
| 沸点 | 503.9±40.0 °C(Predicted) |
|---|---|
| 密度 | 1.819±0.06 g/cm3(Predicted) |
| 储存条件 | Desiccate at RT |
| 溶解度 | 可微溶于水 |
| 酸度系数(pKa) | 2.40±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 100 mM in water |
DCG IV 用途与合成方法
|
mGluR2R 0.35 μM (EC 50 ) |
mGluR3R 0.09 μM (EC 50 ) |
mGluR1R 389 μM (IC 50 ) |
mGluR5 630 μM (IC 50 ) |
mGluR4R 22.5 μM (IC 50 ) |
mGluR6 39.6 μM (IC 50 ) |
mGluR7 40.1 μM (IC 50 ) |
mGluR8 32 μM (IC 50 ) |
DCG-IV is also an NMDA receptor agonist in the rat cortical slice.
DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion.
| Animal Model: | Male ICR mice weighing about 40 g (PCP-induced locomotor activity) |
| Dosage: | 10, 5, or 1 mg/kg |
| Administration: | I.p. |
| Result: | Reduced spontaneous activities of the animals at 10 or 5 mg/kg. |
