2-甲基柠檬酸
2-甲基柠檬酸 性质
| 熔点 | 79 °C |
|---|---|
| 沸点 | 313.1±42.0 °C(Predicted) |
| 密度 | 1.637±0.06 g/cm3(Predicted) |
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 2.93±0.20(Predicted) |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
2-甲基柠檬酸 用途与合成方法
|
Human Endogenous Metabolite
|
2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.
2-甲基柠檬酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-113371 | 2-甲基柠檬酸 | 6061-96-7 | 5mg | 1400 |
| 2024-04-30 | HY-113371 | 2-甲基柠檬酸 | 6061-96-7 | 10mg | 2400 |
