Propargyl-PEG1-t-butyl ester

Product NamePropargyl-PEG1-t-butyl ester
CAS488150-84-1
MFC10H16O3
MW184.23
EINECS
MOL File488150-84-1.mol

Chemical Properties

storage temp.	Storage temp. 2-8°C
form	Liquid
color	Colorless to light yellow
InChI	InChI=1S/C10H16O3/c1-5-7-12-8-6-9(11)13-10(2,3)4/h1H,6-8H2,2-4H3
InChIKey	VDHVLESCKRSEAF-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)CCOCC#C

Usage And Synthesis

Description

Propargyl-PEG1-t-butyl ester has a propargyl group and a t-butyl protected carboxyl group. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005