Azido-PEG3-SS-PEG3-azide is a PEG linker containing two terminal azide moieties and a cleavable disulfide bond. The azide groups can undergo copper-catalyzed Click Chemistry reactions with reagents such as alkynes, DBCO and BCN. The disulfide bond can be cleaved via reduction reactions using a Dithiothreitol (DTT) reagent. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.
Azido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
