ilomastat helps prevent the formation of matrix metalloproteinases. Matrix metalloproteinases are a category of enzymes that contribute to the degradation of the extracellular matrix and its proteins, including collagen. Ilomastat helps prevent the formation of this family of enzymes, which protects the skin’s extracellular matrix. It also inhibits certain strains of bacteria and serves as a chelating agent.
Treatment of corneal ulcers, inflammatory
conditions, and cancers (matrix metalloproteinase
inhibitor).
GM 6001 is a useful negative control for GM 6001. It is a cell permeable fibroblast collagenase inhibitor and antagonizes matrix metalloproteases (MMP) potentially involved in angiogenesis.
Cell permeable: yes', 'Primary Target
MMP-1', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 400 pM for MMP-1; 500 pM for MMP-2; 27 nM for MMP-3; 100 pM for MMP-8; and 200 pM for MMP-9
