LCH-7749944
![LCH-7749944 结构式](https://img.chemicalbook.com/CAS/20200611/GIF/796888-12-5.gif)
LCH-7749944 性质
沸点 | 580.0±58.0 °C(Predicted) |
---|---|
密度 | 1.272±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
溶解度 | 二甲基亚砜:250 mg/mL(713.45 mM) |
酸度系数(pKa) | 7.68±0.30(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
LCH-7749944 用途与合成方法
PAK4 14.93 μM (IC 50 ) |
LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner.
LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.
LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase.
LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner.
Cell Proliferation Assay
Cell Line: | MKN-1, BGC823, SGC7901 and MGC803 human gastric cancer cells |
Concentration: | 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 μM |
Incubation Time: | 24 hours |
Result: | Inhibited the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. |
Apoptosis Analysis
Cell Line: | SGC7901 cells |
Concentration: | 5, 10, 20 μM |
Incubation Time: | 12, 24, 48 hours |
Result: | Induced apoptosis of SGC7901 cells. |
Cell Cycle Analysis
Cell Line: | SGC7901 cells |
Concentration: | 5, 10, 20 μM |
Incubation Time: | 12, 24, 48 hours |
Result: | Prominently induced a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. |
Western Blot Analysis
Cell Line: | SGC7901 cells |
Concentration: | 5, 10, 20, 30 μM |
Incubation Time: | 24 hours |
Result: | Dramatically decreased levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. |
LCH-7749944 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-08-19 | HY-125035 | LCH-7749944 | 796888-12-5 | 5mg | 1980 |
2024-08-19 | HY-125035 | LCH-7749944 | 796888-12-5 | 10mM * 1mLin DMSO | 2178 |