11107B

Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome.

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

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