CID-2011756 (638156-11-3) is a potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 μM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP prostate cancer cells. Cell permeable.
This novel small molecule shows inhibitory activity against PKD1 which control various cellular processes and pathological conditions.
1) Sharlow et al. (2011), Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity; PLoS One, 6 e25134
