8-iso Prostaglandin E2-d4

8-iso Prostaglandin E2-d4 (8-iso PGE2-d4) is intended for use as an internal standard for the quantification of 8-iso PGE2 (Item No. 14350) by GC- or LC-mass spectrometry. 8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.1 It is a potent renal vasoconstrictor in the rat.1,2 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 µM, respectively.3 When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.1WARNING This product is not for human or veterinary use.

[1] J. MORROW. Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanes.[J]. The Journal of Biological Chemistry, 1994, 69 1: 4317-4326. DOI: 10.1016/s0021-9258(17)41781-9
[2] S W HOFFMAN  E F E  S Moore. Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles.[J]. Stroke, 1997, 28 4: 844-849. DOI: 10.1161/01.str.28.4.844
[3] ATKINSON W. LONGMIRE  Jason D M  L Jackson Roberts. Actions of the E2-isoprostane, 8-ISO-PGE2, on the platelet thromboxane/ endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptor[J]. Prostaglandins, 1994, 48 4: Pages 247-256. DOI: 10.1016/0090-6980(94)90011-6