13(S),14(S)-epoxy Fluprostenol isopropyl ester

Fluprostenol isopropyl ester (Item No. 16769) is a potent F-series prostaglandin receptor agonist prodrug that finds clinical use as an ocular hypotensive agent for the treatment of glaucoma.1,2 13,14-epoxy Fluprostenol isopropyl ester (Item No. 13679) is an impurity generated in the production of fluprostenol isopropyl ester. This product is a chiral enantiomer of the epoxide. The pharmacology of 13(S),14(S)-epoxy fluprostenol isopropyl ester has not been studied extensively to date.WARNING This product is not for human or veterinary use.

[1] Travoprost[J]. Reactions Weekly, 2009, 22 1: 40-41. DOI: 10.2165/00128415-200912530-00134
[2] M. HELLBERG. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.[J]. Journal of Ocular Pharmacology and Therapeutics, 2001, 9 1: 421-432. DOI: 10.1089/108076801753266802