Chemokine?ligand 20 (CCL20) is also called as liver and activation-regulated chemokine, macrophage inflammatory protein-3α (MIP-3α) or exodus-1. It is a cysteine?cysteine chemokine, that is located on human chromosome 2q36. It is expressed at high levels in serum or IgA1 and HMC incubation system. The CCL20 promoter region consists of a transcription start site, a nuclear factor (NF)-κB binding site, a CCAAT/enhancer-binding proteins binding site, an activator protein-1 binding sites and a specificity protein 1 (Sp1)-binding site.
Chemokine?ligand 20 (CCL20) is chemotactic for immature dendritic cells, effector or memory CD4+T lymphocytes and B lymphocytes. CCR6 (C-C chemokine receptor type 6), the receptor of CCL20, plays a vital role in the progression of several diseases, such as tumors, rheumatoid arthritis, pneumococcal meningitis and human renal inflammation.
