1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

RN 1747 is a novel TRPV4 modulator.

TRPV4, a close relative of the vanilloid receptor TRPV1, is activated by diverse modalities such as endogenous lipid ligands, hypotonicity, protein kinases and, possibly, mechanical inputs. TRPV4 is a nociceptor playing an important role in inflammatory and neuropathic mechanical hyperalgesia in rodent models apparently specifically activated under pathological conditions.

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