2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one

504-20-1

1197-66-6

General procedure for the synthesis of 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one using 2,6-dimethyl-2,5-heptadien-4-one as starting material: 5 g of 2,6-dimethyl-2,5-heptadien-4-one was dissolved in 36 mL of 1 M hydrochloric acid solution and the reaction was heated for 48 hours at 40 °C. Upon completion of the reaction, the reaction mixture was distilled (63-65 °C fraction was collected) to give 3.0 g of a light yellow oily product in 53% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 1.25 (m, 4H); 2.3 (m, 12H).