A synthesis of angustine has recently been reported. Ethyl oxalate is condensed
with 4-methyl-5-vinylinicotinonitrile followed by condensation of the lactone
thus produced with tryptamine. Hydrolysis and then cyclization of the product
yields angustine.
ChEBI: Angustine is a member of beta-carbolines.
Kametani et ai., Heterocycles, 3, (8) 627 (1975)
