(2-MERCAPTOETHYL)-GUANIDINE SULFATE
(2-MERCAPTOETHYL)-GUANIDINE SULFATE 用途与合成方法
IC50: 11.5 μM (iNOS), 110 μM (ecNOS), 60 μM (bNOS)
MEG (0.1-1000 μM; 18 h) reduces nitrite accumulation in the supernatant of cultured J774.2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL). MEG inhibits iNOS activity in homogenates of lungs taken from LPS-treated rats.
MEG (1 μM-3 mM; 3 min) dose-dependently inhibits the peroxynitrite-induced oxidation of cytochrome c
2+
and hydroxylation of benzoate.
MEG (1-300 μM) inhibits the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite in J774 cells.
MEG (300 μM; 30 min) inhibits the suppression of vascular contractility in response to peroxynitrite in thoracic aortic rings.
MEG (10 mg/kg; i.p. for 5 d) attenuates the degree of lipid peroxidation, protein oxidation, and peroxynitrites level and ameliorated the decrease of antioxidant enzymes activities in the esophagus of rats subjected to caustic burn injury.
MEG (30-60 mg/kg; a single i.p.) decreases mean arterial blood pressure (MAP) of normal rats.
MEG (10 mg/kg; a single i.p.) improves the renal dysfunction and tissue injury induced by ischemia/reperfusion (I/R) of rat kidney.
| Animal Model: | Sprague-Dawley rats (200-250 g) were injured the esophagus |
| Dosage: | 10 mg/kg |
| Administration: | I.p. for 5 days |
| Result: |
Reduced the stenosis index (SI) and the histopathologic damage score.
Decreased the malondialdehyde and protein carbonyl content and increased the activities of superoxide dismutase and glutathione peroxidase. Regulated the nitrate and nitrite level. |
