5,8,11,14-Eicosatetraenoic-5,6,8,9,11,12,14,15-d8 acid, 2,3-dihydroxypropyl ester, (5Z,8Z,11Z,14Z)-

1-Arachidonoyl-d₈-rac-glycerol (1-AG-d₈) is intended for use as an internal standard for the quantification of 1-AG by GC- or LC-MS. 1-AG is a weak cannabinoid (CB₁) receptor agonist and may have other pharmacologic properties.¹ 1-AG is an isomer of 2-AG. 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitro and in vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency.

1. Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB₁ receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca²⁺ transient in NG108-15 cells J. Biochem. 122(4),890-895(1997).