Benzamide, 4-chloro-N-[[[3-[(4-methyl-1-piperazinyl)carbonyl]phenyl]amino]carbonyl]-

HS-152 is a novel reversible inhibitor of smurf1, directly targeting the catalytic activity of smurf hect domains, significantly blocking auto-ubiquitination and the transfer of ubiquitin from hect domain to the substrates to form isopeptide bond