Taurohyocholic Acid-d4 sodium salt

Taurohyocholic acid-d4 (THCA-d4) is intended for use as an internal standard for the quantification of THCA (Item No. 22669) by GC- or LC-MS. THCA is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid (Item No. 20293).1 THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline phase.2 It prevents cholestasis and cellular necrosis induced by taurolithocholic acid (Item No. 17275) in isolated rat liver.3 THCA levels are increased in the urine of patients with hepatitis B-induced cirrhosis.4WARNING This product is not for human or veterinary use.

[1] ANNIKA WAHLSTRÖM. Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism.[J]. Cell metabolism, 2016, 24 1: 41-50. DOI: 10.1016/j.cmet.2016.05.005
[2] CATHERINE JUSTE . Influence of bile salt molecular species on cholesterol crystallization from supersaturated model biles[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1995, 1254 1: Pages 89-97. DOI: 10.1016/0005-2760(94)00172-u
[3] J SCHÖLMERICH. Taurohyocholate, taurocholate, and tauroursodeoxycholate but not tauroursocholate and taurodehydrocholate counteract effects of taurolithocholate in rat liver.[J]. Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1990, 190 2: 121-129. DOI: 10.1007/pl00020014
[4] XIAONING WANG. Serum Bile Acids Are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis[J]. Journal of Proteome Research, 2015, 15 4: 1126-1134. DOI: 10.1021/acs.jproteome.5b00217