基本属性 生物活性靶点体外研究体内研究 用途与合成方法 盐酸氟西汀杂质 价格(试剂级) 供应商 供应信息 相关产品

盐酸氟西汀杂质

盐酸氟西汀杂质

英文名称:N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
CAS号:3545-67-3
分子式:C18H28Cl3N3
分子量:392.79402
EINECS号:2225921
Mol文件:3545-67-3.mol
盐酸氟西汀杂质 结构式

盐酸氟西汀杂质 用途与合成方法

Chloroquine dihydrochloride 是一种广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine dihydrochloride 是autophagy 和toll-like receptors (TLRs) 的抑制剂。Chloroquine dihydrochloride 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。

HIV-1

Malaria

TLRs

SARS-COV-2

Chloroquine dihydrochloride (20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine dihydrochloride (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine dihydrochloride (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine dihydrochloride has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression. TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly reduces HuH7 cell proliferation in vitro.
Chloroquine dihydrochloride (0.01-100 μM; 48 hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13 μM). Chloroquine dihydrochloride blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.

Chloroquine dihydrochloride (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model.
TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine.

盐酸氟西汀杂质 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-11-08 HY-17589B 盐酸氟西汀杂质 50 mg 500

盐酸氟西汀杂质供应商 更多

北京普西唐生物科技有限公司
联系电话:010-60605840 18892239720
产品介绍:
英文名称:Chloroquine dihydrochloride
CAS:3545-67-3
包装信息:100mg;250mg;500mg
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:Chloroquine dihydrochloride
CAS:3545-67-3
包装信息:100mg;250mg;500mg
备注: 试剂级
武汉沃格达生物科技有限公司
联系电话: 15071299552
产品介绍:
英文名称:N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
CAS:3545-67-3
纯度:98%
包装信息:50mg,500mg,2g
备注:自研产品,路线成熟,支持分装定制,质量问题无条件退款,期待您咨询下单!
武汉英诺医药科技有限公司
联系电话:+86-027-59232304 15387063101
产品介绍:
英文名称:N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
CAS:3545-67-3
纯度:98%
包装信息:100mg,500mg,5g
备注:所有产品经第三方检测合格后才发货,质量绝对保证!自家实验室,支持定制!专业客服,等您下单!买试剂,找英诺!
菏泽艾鼎药业有限公司
联系电话: 17661365138
产品介绍:
中文名称:盐酸氟西汀杂质
英文名称:N4-(7-chloro-4-quinolyl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride
CAS:3545-67-3
纯度:97%
包装信息:10g;20g

最新发布供应信息

盐酸氟西汀杂质
陕西西化化学工业有限公司 2024-11-18

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