Epoxy-activated-SepharoseTM is used in affinity chromatography, protein chromatography, and activated/functionalized matrices. Epoxy-activated-SepharoseTM has been used to obtain a monoclonal antibody against the prokaryotically expressed foot-and-mouth disease virus (FMDV) non-structural protein (NSP) 3B as well as to study B meningococcal disease.