anti-Ph-a

Lamin B receptor (LBR) is a transmembrane protein which is expressed in the inner nuclear membrane. It possesses an amino-terminal domain, eight transmembrane domains and a carboxyl-terminal region. The gene encoding LBR is localized on human chromosome 1q42.

Lamin B receptor (LBR) inhibits immature chromatin binding of proteins. It has a role in the construction of the nuclear envelope in vitro and in vivo. Mutation in the gene encoding LBR has been linked to Pelger-Hut anomaly (PHA).