GNE-8324 is a potent and selective NMDA receptor PAM.
This study showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity in vitro and in vivo._x000D_
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Reference: Front Pharmacol. 2022 Jan 4;12:796179. https://pubmed.ncbi.nlm.nih.gov/35058780/
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons.
